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Neurobiology of the NMDA receptor from chemistry to the clinic by

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Published by VCH in New York, N.Y .
Written in English


  • Methyl aspartate -- Receptors.,
  • Neurobiology.,
  • Synaptic Receptors.

Book details:

Edition Notes

Includes bibliographical references and index.

Statementedited by Alan P. Kozikowski ; associate editor, German Barrionuevo.
ContributionsKozikowski, Alan P., Barrionuevo, German.
LC ClassificationsQP364.7 .N4417 1991
The Physical Object
Paginationxii, 253 p. :
Number of Pages253
ID Numbers
Open LibraryOL1859957M
ISBN 100895737698, 3527279296
LC Control Number90013153

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NMDA RECEPTORS IN NEUROLOGICAL DISEAESES. Glutamate is the major excitatory neurotransmitter in the CNS which acts on ionotropic and metabotropic glutamate receptors located at the presynaptic terminal and in the postsynaptic membrane at synapses in the brain and spinal cord (Figure 1).There are three pharmacologically and molecularly distinct subtypes . NMDA receptor activation leads to opening of an ion channel that is selective for cations, resulting in the influx of Naþ and Ca2þ ions and efflux of Kþ ions. Although most glutamate receptors are cation selective,ep-tional calcium permeability is the first of two key properties of the NMDA receptor that. Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological. Neurobiology of the NMDA receptor: from chemistry to the clinic. neuroscientists, medical students, and practitioners, this book discusses such topics as the chemical pharmacological and biophysical properties of the \u00A0\u00A0\u00A0\n rdfs:label\/a> \" Neurobiology of the NMDA receptor.\/span>\" ; \u00A0\u00A0\u00A0\n schema.

  Anti- N-methyl-D-aspartate (NMDA) receptor encephalitis is a fascinating disorder that was first described in Initially thought to be exclusively a paraneoplastic disorder occurring in young females with an ovarian teratoma, it is now recognised that this syndrome can occur in children and adults with or without a tumour. This book comprises an up-to-date and comprehensive coverage of the NMDA receptor. The NMDA receptor is an important protein in the brain which is involved in physiological processes such as synaptic transmission and synaptic plasticity which may underlie learning and memory. Pathological changes involving the NMDA receptors probably contribute Cited by: Daniel A. Llano, Steven L. Small, in Neurobiology of Language, Human Studies: Memantine. Memantine is a noncompetitive NMDA-receptor antagonist currently approved for the treatment of Alzheimer disease. A single trial has been performed examining the efficacy of memantine to treat chronic aphasia due to stroke. The NMDA receptor, an important protein in the brain, is involved in physiological processes such as synaptic transmission and synaptic plasticity which may underlie learning and memory. Pathological changes involving the NMDA receptors probably contribute to the development of epilepsy, acute neuronal damage such as that resulting from a stroke, and chronic .

  Homayoun, H. & Moghaddam, B. NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons. J. Neurosci. 27, Cited by:   Dalmau, J. et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 7, – ().Anti-NMDAR encephalitis is a newly discovered Cited by: Cutting-edge and practical, NMDA Receptors: Methods and Protocols is a valuable resource that discusses the diversity of the currently-used methods, the importance of NMDARs and their complexity, and the progress that has already been made. This book will be of interest to scientists, clinicians, and industry professionals working in this field. Book Description. The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains.